This course will provide training in the experimental and computational approaches.
However, we are only beginning to systematically understand how the interplay of DNA, proteins and its biochemical modifications (i.e. chromatin) can influence global processes which control gene expression, mRNA splicing, and DNA replication or repair in normal development and in disease.Learning Outcomes: After attending the course, participants can expect to be able to: - Perform chromatin immunoprecipitation, 3C and Capture C, and DNA methylation techniques, including experimental design and end-point analysis. - Understand the methods used in the preparation of material for next generation sequencing (NGS) - Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci. - Download and install relevant software, and manage large datasets. - Understand how polymer physics can be used to build models of chromatin structures
Participants will receive intensive laboratory and computational training in state-of-the-art approaches focussed across five broad themes: - DNA/transcription factor interactions - DNA methylation - Histone dynamics and modifications - Chromatin accessibility, looping and nuclear organisation - Computational analysis/integration of chromatin datasets
These sessions will be supplemented with informal tutorials and lectures from the instructors and distinguished invited speakers. Participants will analyse the various genome-wide data generated in parallel to or during the laboratory sessions. They will also have an opportunity to discuss their own research interests and present aspects of their work that are relevant to the course.
Speakers: Course instructors: David Vetrie (University of Glasgow, UK), Nick Gilbert (University of Edinburgh, UK), Lee Stirling (Imperial College London, UK), Robert Andrews (Cardiff University, UK) Guest speakers: Adele Murrell (University of Bath, UK), Nada Jabado (McGill University, Canada), Dirk Schübeler (Friedrich-(Miescher-Institute for Biomedical Research, Switzerland), Henk Stunnenberg (Radboud University, The Netherlands)
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VenueWellcome Genome Campus
Address, Hinxton, Cambridgeshire,
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The Red Lion Hinxton
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The Red Lion Hotel
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Close to Duxford Airfield and the historic city of Cambridge, this homely B&B offers free Wi-Fi and free parking on site. It is situated in Whittlesford, just 5 minutes drive from the M11 motorway..
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